Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddingsArticle Published on 2023-12-012022-11-15 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] 치료제, [키워드] antiviral properties binding affinity cells Cheminformatics Compound compounds conducted coronavirus dataset dose-dependent inhibition drug design Drug discovery evaluate half-maximal inhibitory concentration in silico inhibitor inhibitory effect ligand-based drug design M pro Machine learning. machine-learning molecular protease Protease inhibitor screened selected thought Toxicity Virtual screening virus infectivity [DOI] 10.1080/14756366.2022.2132486 PMC 바로가기
Evaluation of indirect sequence-specific magneto-extraction-aided LAMP for fluorescence and electrochemical SARS-CoV-2 nucleic acid detectionArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 변종, 치료기술, 치료제, [키워드] amplification approach circumvent clinically Disadvantages Electrochemical LAMP Host in silico inhibitor investigated isothermal isothermal amplification Magnetic sequence-specific target enrichment molecular NAAT nucleic acid Nucleic acid detection PCR polymerase probe qRT-PCR Quantitative Quantitative real-time LAMP real-time reverse transcriptase restrict SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 variant SARS-CoV-2. sensitivity sequence serum turn [DOI] 10.1016/j.talanta.2022.123809 PMC 바로가기
Molecular detection of SARS-COV-2 in exhaled breath at the point-of-needArticle Published on 2022-12-012022-11-15 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Aerosols Analysis Antigen approach approach breath contagious contagiousness detect diagnostics Direct equipment help identify impactor Infection Lab-on-a-chip less limitation molecular Nasopharyngeal swab offer Particle Pathogens patients PCR positive quantification respiratory infections RT-qPCR Saliva SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2. Spread subject temporal dynamics tested Viral load Viral RNA viral shedding Volume while [DOI] 10.1016/j.bios.2022.114663 PMC 바로가기
Molecular and pro-inflammatory aspects of COVID-19: The impact on cardiometabolic healthArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 진단, [키워드] affected cardiometabolic cardiovascular Cluster Complication country COVID COVID-19 COVID-19 pandemic COVID-19 severity CVD cytokine cytokine production diabetes Final hallmark Health hypertension IL-6 IL10 IL2 IL4 IL8 immune system increased the risk infected patient Inflammation inflammatory state influence molecular molecular. morbidity and mortality obese pathophysiological Patient predictor pro-inflammatory reported resulting SARS-CoV2 systemic damage target type 2 diabete virus [DOI] 10.1016/j.bbadis.2022.166559 PMC 바로가기
Disease severity and efficacy of homologous vaccination among patients infected with SARS-CoV-2 Delta or Omicron VOCs, compared to unvaccinated using main biomarkersArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, [키워드] AstraZeneca Biomarker booster case-control study caused Chronic diseases Clinical severity conducted country COVID-19 COVID-19 confirmed patient COVID-19 patient COVID-19 vaccination COVID-19 vaccine CRP level Delta delta variant Delta wave dose doses effective Effectiveness Efficacy expressed females Health homologous homologous vaccination. hospital Hospitalization Hospitalized individual infected with SARS-CoV-2 Iraq Lower males molecular no significant difference no significant effect omicron Omicron variant pandemic Patient patients Pfizer Population Prevent recommendation recorded risk SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant severity significantly Symptom the disease the vaccine transmissibility of SARS-CoV-2 vaccination Vaccine variant variants of concern virus VOCs was done WBC [DOI] 10.1002/jmv.28098 PMC 바로가기
Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules’ fifth labourArticle Published on 2022-12-012022-11-15 Journal: Pharmaceutical Biology [Category] 치료제, [키워드] active against analysis antiviral activity antiviral drug antiviral drugs Asia Asian ChemSpider Direct distribution Google Scholar Hercule hydroxytyrosol identify in vivo material molecular natural plant PubChem RNA RNA virus RNA virus Science Treatment viral genome replication viral infections virus virus Web of Science with COVID-19 zoonotic [DOI] 10.1080/13880209.2022.2130944 PMC 바로가기
Sudden unexpected death in a 17-year-old boy due to unacknowledged adamantinoma-like Ewing sarcomaArticle Published on 2022-12-012022-11-15 Journal: Forensic Science, Medicine, and Pathology [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, [키워드] Abnormalities Adamantinoma-like Ewing sarcoma addition airway Airway occlusion Analysis analysis anatomical Autopsy Blood Brain break cardiac cause CD99 Cell characterized Chest radiography Complete death diagnosed diagnostic diagnostics died discharged disease Dyspnea EWSR1 excluded expression Forensic Forensic autopsy forensic pathology Germany histopathological hospital immunohistochemistry Invasion Leica Local lung macroscopic male mechanism Microscopy Mild molecular Nasopharyngeal swab neoplasm nucleoli organ oxygen saturation pathology probe SARS-CoV-2 Soft tissue subject sudden Sudden unexpected death. tested Thyroid was performed [DOI] 10.1007/s12024-022-00525-x PMC 바로가기
Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDSSARS-CoV-2에 의해 유발된 ARDS 생존자의 폐 기능 및 방사선학적 특징과 관련된 순환 microRNA 프로파일 식별Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory distress syndrome Anti-inflammatory ARDS association carbon monoxide cell death Chest computed tomography circulating Coagulation Complete composed Computed tomography conducted correlated COVID-19 develop diffusing diffusing capacity distress enrichment analyses enrichment analysis evaluated Evidence evidence of feature Features Follow-up Gene ontology genomes hospital discharge hypoxia identification immune response infected patient infected patients KEGG KEGG pathway Kyoto lung Lung function median microRNA miR-126 miR-146 miR-146a-5p miR-21 miR-9 miRNA miRNA profiles miRNA profiling miRNA signature molecular molecular mechanism molecular mechanisms Pathogenesis pathophysiology pathway Patient patients predicted profile provided Pulmonary function radiologic radiological feature radiological features Random forest respiratory distress Respiratory distress syndrome RT-qPCR SARS-COV-2 infection secondary to sequelae severe COVID-19 severity survivor to define total severity score. Trial registration TSS vascularization viral infection was performed was used [DOI] 10.1080/22221751.2022.2081615 PMC 바로가기 [Article Type] Article
B cell receptor signatures associated with strong and poor SARS-CoV-2 vaccine responses강력하고 불량한 SARS-CoV-2 백신 반응과 관련된 B 세포 수용체 신호Article Published on 2022-12-012022-09-12 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, [키워드] age antibody Antibody Response B cell B cell receptor Biomarker class switch recombination clone Cohort COVID-19 healthy IgG IgM Immunity inactivated Inactivated vaccine inactivated vaccine. individuals Infection molecular mRNA Neutralizing antibodies receptor recipient Reinfection response SARS-CoV-2 SARS-CoV-2 vaccine the antibody response vaccinated individual vaccination Vaccination strategies vaccine-induced antibody response [DOI] 10.1080/22221751.2022.2030197 PMC 바로가기 [Article Type] Article
Highly sensitive and rapid detection of SARS-CoV-2 via a portable CRISPR-Cas13a-based lateral flow assayArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome addition amplification approach assays clinical sample comparable component Concentration coronavirus disease Coronavirus-2 COVID-19 CRISPR Diagnostic method Effectiveness ENhance examined identify immunochromatographic IMPROVE individual isothermal lateral flow lateral flow assay lateral flow strip limit of detection molecular polymerase chain primer probe Protein provide Quality control reliability Result reverse transcription RNA RT-PCR SARS-CoV-2 screened sensitive detection. sensitivity significantly Spread tested virus detection [DOI] 10.1002/jmv.28096 PMC 바로가기